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  • Measure, analyse, control


    Measure, analyse, control

    The systems we supply are used at all stages in research, development and manufacturing

    Our systems enable you to measure, analyse and control a broad range of properties and characteristics across a wide range of sample types.

Manufacturing Processes for Engineered T-Cell Therapy – CAR-T

Why T-cells are important

  • They recognize host vs. non-host cells to initiate an immune response
  • They’re the primary immune system agents that attack diseased cells or infection
  • They’re used in several cell-based therapies:
    • Transplantation of donor T-cells – a bone marrow transplant, in which a matched donor’s cells are used to replace the patient’s cells, is the most widely used approach—typically for diseases that originate in the immune system (e.g., leukemia)
    • Isolation and enrichment of a patient’s T-cells – an approach considered the safest because it enhances a patient’s own immune response to disease
    • CAR-T therapy – a more recent approach in which T-cells are removed, genetically engineered to express a synthetic receptor against specific cancer cells, then infused back into the patient’s bloodstream; this therapy is effective because many cancer cells “hide” from the immune system by appearing to be normal cells, thereby triggering no immune response