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Horiba Scientific
ViewSizer 3000

Simultaneous Multi-Laser Nanoparticle Tracking Analysis (NTA)

  • Measurement range 10 nm – 15 µm
  • Concentration Measurement Range: 1E5 to 1E9 particles/mL
  • No cross-contamination

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Beckman Coulter LS 13 320 XR Laser Diffraction Particle Size Analyser 21 CFR Part 11

Exosomes? Virus? Nanoparticle? Use multiple lasers for complete, detailed analysis of all the particles in your sample.

Exosomes, viruses, and nanoparticles all have wide size distributions which defeat traditional Nanoparticle Tracking Analysis (NTA) analyzers. The ViewSizer 3000 features simultaneous measurement with three lasers to collect the most accurate distribution and concentration information over a wide range of sizes within the same sample. Where the signal from a particle is too bright and saturates the detector from one laser, the software automatically uses data from a lower power laser to ensure the most accurate size and concentration information. On the other hand, when scattering from one laser is too weak for detection, the software uses data from a higher power laser to accurately track the particle.

Cross contamination is a concern in all analyses. Simplified cleaning means thorough cleaning. The easy-to-remove sample cells can be dissassembled for rapid, thorough cleaning, which leads to better data.

Escape the limits of traditional Nanoparticle Tracking Analysis

Accurate and sensitive analysis without cross contamination

Applications

Vaccine Manufacturing


Infectious Titer

Emulsion Polymerisation


Whiskey

Powder Metallurgy

Protein Aggregation


Exosomes

Protein Therapeutics

Drinking Water

Extracellular Vesicles

Features

The ViewSizer 3000 uses the latest advances in nanoparticle tracking analysis (NTA) to accurately determine particle properties!

Size Measurement Range: 10 nm to 15 microns depending on sample
The ViewSizer determines particle size and size distribution details by multi-laser nanoparticle tracking analysis (NTA). Multiple lasers enable analysis of a broad range of sizes in the same sample.
Concentration Measurement Range: 1E5 to 1E9 particles/mL
NTA can be used to count particles in the measurement volume. A patented method corrects for the effect of particle size on effective measurement volume.
No cross-contamination
The sample cell can be completely removed and dissassembled for complete cleaning. Disassembly, cleaning, and reassembly is faster than rinsing a flow cell. Furthermore, multiple cells can be used for faster throughput or assigned to various groups in a shared (core) facility.

Featured Publications for the ViewSizer 3000:

A lipase-independent pathway of lipid release and immune modulation by adipocyteshttps://science.sciencemag.org/content/363/6430/989
Application of a novel new multispectral nanoparticle tracking techniquehttps://iopscience.iop.org/article/10.1088/1361-6501/aab940/meta
Biophysical characterization of polydisperse liposomal adjuvant formulationshttps://doi.org/10.1016/j.bbrc.2020.05.156
Characterisation of particles in solution – a perspective on light scattering and comparative technologieshttps://doi.org/10.1080/14686996.2018.1517587
Cyclodextrin Reduces Intravenous Toxicity of a Model Compoundhttps://doi.org/10.1016/j.xphs.2019.01.004
Development and anti-Candida evaluation of the vaginal delivery system of … nanosuspension-loaded thermogelhttps://doi.org/10.1080/1061186X.2018.1434660
Electrochemical sensor based on F,N-doped carbon dots decorated laccase for detection of catecholhttps://doi.org/10.1016/j.jelechem.2019.03.071
Light scattering by pure water and seawater: the depolarization ratio and its variation with salinityhttps://doi.org/10.1364/AO.58.000991
Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosishttps://doi.org/10.1016/j.ymthe.2018.05.014
Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cellshttps://doi.org/10.1038/s41598-020-67039-w
Multifunctional Nanocomposites Based on Liposomes and Layered Double Hydroxides Conjugated with Glycylsarcosine for Efficient Topical Drug Delivery to the Posterior Segment of the Eyehttps://doi.org/10.1021/acs.molpharmaceut.8b01136
Particle size analysis of polydisperse liposome formulations with a novel multispectral advanced nanoparticle tracking technologyhttps://doi.org/10.1016/j.ijpharm.2019.06.013
Review of nanoparticles in ultrapure water: definitions and current metrologies for detection and controlhttps://www.ovivowater.com/review-of-nanoparticles-in-ultrapure-water-definitions-and-current-metrologies-for-detection-and-control/
Spark erosion as a high-throughput method for producing bimodal nanostructured 316L stainless steel powderhttps://doi.org/10.1016/j.powtec.2018.01.012
Synthesis and Characterization of EGFR-Targeted Immunoporphysomeshttp://hdl.handle.net/1807/89548
Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditionshttps://pubs.acs.org/doi/abs/10.1021/acsabm.9b00747
Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles | Protocol (jove.com)https://doi.org/10.3791/62447
Isolation and characterization of EV in Saliva of Children with Asthmahttps://evcna.com/article/view/3962
Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potentialhttps://doi.org/10.1016/j.bbi.2020.12.007
Skeletal muscle tissue secretes more extracellular vesicles than white adipose tissue and myofibers are a major source ex vivo but not in vivohttps://doi.org/10.1101/2020.09.27.313932
Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islandshttps://www.nature.com/articles/s41598-021-84809-2
Purification of Cas9 – RNA Complexes by Ultrafiltrationhttps://doi.org/10.1002/btpr.3104
Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applicationshttps://doi.org/10.1002/smtd.202100785
Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegenerationhttps://doi.org/10.1172/jci.insight.155928
Circulating Extracellular Vesicles From Septic Mice Induce Brain Inflammation via Mirna Cargohttp://hdl.handle.net/10713/19055

Specifications

Measurement Range

10 nm to 15 μm

Typical Sample Volume

350 µL to 2.5 mL

Typical Sample Concentration
(Sample dependent)

10^5 – 10^9 particles/mL/p>

Sample Temperature Range
(Controlled)

10° C to 50° C +/- 0.1° C

Dimensions

55 cm W x 66 cm D x 35 cm H

Weight

27 kg

Operational Environment

15° C to 30° C with < 85% RH

Not sure if it’s the right instrument?

No worries, send us a sample and we will test it for you

Send a sample

Outstanding service

I have been using Meritics for a number of years and they always provide outstanding service and support.
They have a rapid response turnarounds and are very knowledgeable of the techniques and products they provide.

LeanneB-375

Good service, very helpful

We use Meritics for the PM service and installation of all our FlowCams . Megan has been coming to our site for a number of years. She is very efficient in her work, but most of all Megan is very helpful. We have had issues with one of instruments after the install and Megan did her utmost to try and solve it while on site, even though it wasn’t solved Megan has been in contact with the supplier of the instrument to try and solve this problem for us.

SophieH-2201

Job done in a friendly manner

Booking engineer visits is always easy. David Lowe, Meritics engineer is always very friendly.

ThierryN

Service/calibration visit

Excellent service, arrived on time, polite, friendly and informative.

NathamM-270

5 Stars

Excellent service from an excellent company. Would recommend them to anyone.

BarryH-480

Good Service

David, our service engineer as usual was good at communicating and setting up the recent service appointment, he arrived on time, did the service promptly and informed me of any problems. Friendly and helpful

TomA-446

Superb and prompt service

I have used this company through the laboratory I work for frequently. We specialise in soil analysis, and Meritics were chosen as they have extensive knowledge of the instruments we use. We have several laser particle diffraction analysers with a service contract, and service is always very prompt and meticulous….

JamesG-2483

Good experience over two years

Meritics have covered the annual servicing of our Multisizer 4e instrument since we purchased it from them just over two years ago. The application scientist who performed the servicing was friendly, knowledgeable, and extremely helpful, happily answering a barrage of questions about how best to use and maintain the instrument. All my interactions with Meritics staff have been positive. I would happily recommend them.

RajG-62

Fully committed to customer service

Service second to none, both units serviced and all questions answers by engineer while on site.

RichardA-786

Highly recommend Meritics for equipment purchases and aftercare services

After owning one of our instruments for over 8 Years which was purchased from Meritics, it suffered its first breakdown. Upon contacting Meritics, I was instantly put through to an engineer who was very helpful. Upon inspection of the manual, it was decided that it would be more cost effective to have a Meritics engineer visit. The Meritics staff were very communicative and kept me up to date.

Excellent Service

Lovely, friendly and extremely helpful. David and his team are always on call with advise and are very easy to work with and are always happy to help.

NaomiT-64

Service of lab equipment

Excellent service. Friendly and professional service was provided in a timely manner to the expected standard.

NathanM-270

Excellent

Excellent communication. Updates given well in advance. Very polite staff and engineers.

NathanM-270

Multisizer 4e install at pharmaceutical company

2 people helped with the install of a Multisizer 4e. They were both very professional and friendly, answering any questions that I had. The installation was quick and the attention to good documentation practice was exceptional.

Chloel-9

Service of Beckman Coulter instruments

Always a pleasure to welcome the Meritics service engineer, who is knowledgeable, personable and extremely competent.

NeilT-394

Professional

Friendly and collaborative staff, provided a very good service.

SamK-403

Professional, Customer-oriented, fast service

We had issues with one of the aperture tubes provided by Meritics on a Friday afternoon, while very pressed for a review deadline. Meritics handled our inquiries very fast and professionally and helped us out by shipping us their spare tube to use in the mean time free of charge, while we waited for our new tube to arrive. Communication was very pleasant.

VeerleB

Very helpful and prompt

I emailed for some technical help and also to get some spares and both the engineer (David) and purchasing (Sophie) were very prompt to respond and helpful. We do have a service contract but I appreciated being able to email the engineer directly.

AlexH-474

Excellent Service

Used Meritics to conduct particle size distribution by laser diffraction. Service as last time, is very quick, well priced and professional.

I would highly recommend

GavinR-101

Excellent and Friendly Service

Always a pleasure to deal with the people at Meritics Ltd. They understand the importance of our work and the fact that our research projects have deadlines that need to be met. Consequently, problems are dealt with very quickly and professionally and they are willing to go that one step further to make sure their supply chain problems don’t become our problems. Thank you to the team for their support. It is greatly appreciated.

JanetH-255