Drug discovery application: Determination of dissociation constant (KD) between a fragment and a protein
Drug discovery is a long and rigorous process, and there are many approaches from different branches of science to find ideal drug candidates. Fragment based drug discovery has been established as a strategy to identify small compounds that can be further developed into leads and clinical candidates (1, 2). Fragment compounds are typically < 300 Da in size (3), and they are typically screened against a target protein.
