Bettersize BeScan Lab+

What BeScan Lab+ Provides? 

• Backscattering and Transmission Profiles
• lnstability index (l_us)
• Particle Size and Particle Size Distribution
• Homogeneity Index
• Hydrodynamic Analysis
• Kinetic Parameters
• Photon Mean Free Path Analysis
• AI-Powered Analysis

Features & Benefits

Native-State Analysis

Non-Destructive measurement
Preserves the sample’s original state with non-contact, dilution-free, and shear-free analysis.

Exceptional Concentration Range  
Accurately measures sample dispersions from very dilute up to 95% volume fraction.

Broad Particle Size Range  
Supports particle sizes from 0.01 to 1,000 μm, enabling reliable analysis of both nano- and micro-scale dispersions.

High-Precision & High-Throughput Hardware

Ultra-Sensitive Optical System 
Achieves up to 200×  greater sensitivity than visual inspection, enabled by precise 20 μm vertical scanning step.

Scalable, High-Throughput Testing 
Supports simultaneous connection of up to 10 units, dramatically increasing testing capacity and efficiency.

Advanced Temperature Control 
Features a wide operating range from 10 °C below ambient up to 80 °C, ensuring reliable performance under controlled thermal conditions.

Intelligent Data Analysis & Comprehensive Profiling

Quantitative Stability Metrics 
Utilizes Instability (I_US) and Homogeneity (RSD) indices to precisely quantify stabilization and destabilization kinetics.

Mechanism & Particle Size Analysis 
Identifies instability mechanisms (e.g., creaming, sedimentation) while delivering real-time, in-situ particle size distribution (PSD) analysis.

AI-Powered Diagnostics & Traceability 
AI-driven analysis diagnoses root causes of instability and recommends formulation improvements, supported by barcode-based sample tracking for streamlined data management.

 AI-Driven Instability Diagnosis 

Make complex data easier to interpret — and faster to act on.

Interpreting stability data traditionally relies on experience, time, and consistent expertise across teams. The BeScan Lab+ addresses these challenges with an integrated AI-powered interpretation engine that transforms complex optical data into clear, decision-ready insight.

By combining signal evolution patterns with industry context and sample type, the system automatically identifies likely instability behaviors and supports root-cause analysis. This reduces reliance on manual interpretation and enables teams to reach conclusions faster, more consistently, and with greater confidence.

What AI Brings to Your Workflow

• Faster, more intuitive data interpretation
• Standardised analysis across users and teams
• Reduced dependence on expert-only judgment
• More efficient formulation screening
• Stronger support for optimization and QC decisions

Examples of AI-Identified Instability Behaviors

Droplet coalescence in cosmetic emulsions					Sedimentation and agglomeration in CMP slurries
AI Analysis					AI Analysis
Instability Index	Total: 7.0 / Bottom: 6.7 / Middle: 7.4 / Top: 6.8				Instability Index	Total: 4.0 / Bottom: 3.2 / Middle: 1.7 / Top: 7.1
Phenomenon	Aggregation, both bottom and top concentrations stable, but particle flocculation/aggregation occurs within the system.				Phenomenon	Sedimentation with Top Clarification and Aggregation, bottom concentration increased, top concentration decreased, accompanied by particle aggregation.

Sedimentation and gelation in battery slurries					Creaming in food emulsions
AI Analysis					AI Analysis
Instability Index	Total: 0.1 / Bottom: 0.1 / Middle: 0.1 / Top: 0.2				Instability Index	Total: 1.5 / Bottom: 1.5 / Middle: 1.3 / Top: 2.0
Phenomenon	Sedimentation with Top Clarification and Aggregation, bottom concentration increased, top concentration decreased, accompanied by particle aggregation.				Phenomenon	Bottom Clarification with Creaming and Aggregation, bottom concentration decreased, top concentration increased, accompanied by particle aggregation.

The result: Stability testing evolves from passive observation into intelligent decision support, accelerating development and improving confidence at every stage.

 Full Lifecycle Stability Solutions 

The BeScan Lab+ supports the entire product lifecycle by helping teams detect risk earlier, optimize faster, and control quality with greater confidence. Stability is not a single checkpoint. It is a continuous challenge that directly impacts development speed, manufacturing consistency, shelf-life reliability, and in-use performance. The BeScan Lab+ enables proactive, quantitative, and actionable stability management — from raw material selection to end-user application.

Formulation Development			Quality Control & Process Optimization
Raw Material Screening & Formulation Optimization			Batch Consistency and Release Testing
Typical challenge			Typical challenge
Too many variables, too many formulation candidates, and heavy reliance on slow, subjective visual comparison.			Changes in process parameters or batch variability can compromise long-term stability, even when products appear acceptable in the short term.
What the BeScan Lab+ reveals			What the BeScan Lab+ reveals
Early-stage stability differences between raw materials, suppliers, additive systems, and formulation ratios – enabling faster screening and smarter formulation decisions.			Subtle stability differences driven by process conditions such as mixing intensity, emulsification time, and temperature – supporting robust process control and batch-to-batch consistency.

Storage & Transport Simulation			Application Performance
Shelf-Life Prediction & Environmental Stress Testing			Redispersibility & In-Use Performance
Typical challenge			Typical challenge
Storage and transport conditions can trigger separation, sedimentation, or structural change over time.			A product may remain stable during storage but fail to redisperse or perform as expected during real-world use.
What the BeScan Lab+ reveals			What the BeScan Lab+ reveals
How instability develops under different temperature and time conditions, enabling realistic simulation of storage, transport, and shelf-life scenarios.			Whether a system can redisperse effectively after shaking, dilution, or sonication – ensuring consistency and performance at the point of application.

 Integrated Stability Platform 

The BeScan Lab+ also integrates with the broader Bettersize portfolio to deliver a deeper, more connected understanding of both internal and external stability factors. When combined with BeNano, Bettersizer, BetterPyc 380, BeSEC, and BeVision, users can build a comprehensive and data-driven stability workflow spanning formulation, processing, structure, and performance.

Static Multiple Light Scattering  

Static Multiple Light Scattering (SMLS) is an optical technique used to directly characterize native concentrated liquid dispersions. This technique emits light into the sample, where it is scattered multiple times by particles or droplets before being detected.

BeScan Lab applies SMLS using an 850 nm LED as light source, with detectors set at 0° for capturing transmitted light and at 135° for backscattered light. This setup scans the sample vertically, analyzing the transmitted light for transparent systems, while the backscattered light is ideal for opaque systems.

The signals are collected at 20 μm intervals, which enables precise observation of changes in size (d) and concentration (Φ) of suspended materials.

Signal display

Customized scanning procedures allow presentation of scans with different colors corresponding to different scanning times. The overlap of scans demonstrates how signals diverge from the reference as they vary with height and time. Intuitively, the scans capture local changes that characterize unstable phenomena.

The example illustrates that during sedimentation, the backscattered signals (dBS) undergo a distinctive pattern of change: a decrease at the top and an increase at the bottom, which is attributed to the migration of particles.

Features

• Versatile measurement

No limitations on color or viscosity, and suitable for a wide range of samples from low to high concentrations (up to 95% v/v).

• Non-destructive and in situ 

Measures without preparation, thus preserving the sample’s original characteristics.

• Wide particle size range

Capable of measuring particles from 0.01 to 1,000 μm.

• Applicable to various systems

Suitable for emulsions, suspensions, foams, and other dispersions, providing robust and high-resolution measurements.

 Quantify Stability with the Instability Index 

One metric. Objective comparison. Confident decisions.

The Instability Index (I_US) is the core quantitative output generated by the BeScan Lab+. Derived from time-dependent optical signal changes across the entire sample height, I_US translates complex destabilization behavior into a single, clear and comparable metric.

Higher I_US values indicate lower stability, enabling rapid, objective assessment across formulations, batches and conditions.

Why I_US Matters

• Enables objective quantitative stability comparison
• Simplifies formulation ranking and screening
• Supports batch-to-batch benchmarking
• Tracks stability trends in real time
• Strengthens data-based release and optimization decisions

How It Supports Better Decision Making

• Compare multiple samples on a single consistent scale
• Quickly identify the most and least stable formulations
• Track how stability evolves over time
• Detect instability well before visible failures occur
• Establish consistent evaluation standards across teams

Detect instability earlier. Optimize sooner, before failure becomes visible.

 From Data to Decisions 

Go beyond detection. Build deeper understanding. Make better decisions.

The BeScan Lab+ links macroscopic instability to microstructural evolution and kinetics, enabling users to move from signal interpretation to actionable formulation strategy.

Average Particle Size & Migration Kinetics		Sedimentation Particle Size Distribution
Tracks interface movement and calculates particle or droplet migration rates over time.		Monitors time-dependent changes in transmitted light and applies Stokes’ Law and Beer’s Law to determine particle size distribution without dilution.

Homogeneity Index		Stability Radar Chart
Quantifies vertical concentration uniformity using standard deviation (SD) and relative standard deviation (RSD) across the full sample height.		Integrates Instability Index (IUS) values from the top, middle, bottom, and overall sample zones to rapidly identify the most unstable regions.

From raw optical signals to confident formulation decisions — the BeScan Lab+ delivers the complete stability picture.

* Depends on sample properties and preparation.
** Testing below room temperature requires an external cooling device.
† For operation below room temperature, maintain ambient relative humidity below 20%.

Flexible Accessories for Extended Testing Needs

Designed for real-world laboratory and industrial workflows, the BeScan Lab+ easily adapts to diverse sample types and testing 
conditions. A range of flexible accessories extends capability while maintaining ease of use and measurement reliability

Coring Sample Cell Optimized for high-viscosity paste, cream, and foam.
Low-volume Sample Cell 2–4 mL capacity, ideal for precious or limited-volume samples.
Cooling Module Extends temperature control down to 10°C below ambient temperature.
Low-speed Centrifuge Ensures flat meniscus formation and bubble-free preparation for viscous samples.