Reliability you can count on: 3-Year Warranty from Bettersizer

Peace of Mind with a 3-Year Bettersize Warranty

Bettersize Instruments provides a 3-year warranty on its particle characterisation instruments, giving you confidence in your investment and dependable performance from day one. The warranty provides valuable protection against unexpected issues and helps keep your particle analysis equipment operating reliably throughout the warranty period. As part of this commitment to long-term customer support, we also provide complimentary software upgrade assistance throughout the instrument’s life cycle, helping ensure your system remains supported and benefits from relevant software improvements.

Cost Savings and Predictable Ownership

A 3-year extended warranty from Bettersize Instruments can make the cost of ownership easier to manage. Unexpected repairs, replacement components and technical call-outs can quickly increase operating costs, particularly when an instrument plays an essential role in laboratory testing or quality control.

An extended warranty provides greater financial predictability by reducing the risk of unexpected repair expenses. This makes it easier to plan maintenance budgets and manage the long-term cost of your particle analysis equipment.

Minimise Downtime

Laboratory downtime can delay testing, affect production schedules and disrupt research programmes. Our technical support helps resolve issues quickly and efficiently, allowing you to return to routine analysis as soon as possible.

Access to professional technical assistance also means you have experienced support available when you need it, helping reduce disruption and maintain productivity.

Maintain Long-Term Performance

Regular maintenance and the use of genuine Bettersize replacement parts help protect instrument performance over the long term. Proper maintenance supports reliable operation and helps maintain the accuracy and precision required for consistent particle size analysis.

Protect Your Investment

A 3-year warranty provides more than financial protection. It gives you confidence that your Bettersize instrument has professional support behind it throughout its early years of operation. Combined with technical assistance, genuine parts and complimentary software upgrade assistance, the warranty helps you maximise the performance, reliability and working life of your particle characterisation instrument.

Instruments available from Bettersize

Comparing FlowCam Results with Light Obscuration: A Study by Japan’s National Institute of Health Sciences

In their recent publication, Quantitative Evaluation of Insoluble Particulate Matters in Therapeutic Protein Injections Using Light Obscuration and Flow Imaging Methods, Shibata et. al. compare the ability of Light Obscuration and Flow Imaging to detect and accurately characterize subvisible particles in injectable drugs.

The team at Japan’s National Institute of Health Sciences write the following:

Flow imaging (FI) has emerged as a powerful tool to evaluate insoluble particles derived from protein aggregates as an orthogonal method to light obscuration (LO). However, few reports directly compare the FI and LO method in the size and number of protein particles in commercially available therapeutic protein injections. In this study, we measured the number of insoluble particles in several therapeutic protein injections using both FI and LO, and characterized these particles to compare the analytical performance of the methods. The particle counts measured using FI were much higher than those measured using LO, and the difference depended on the products or features of particles. Some products contained a large number of transparent and elongated particles, which could escape detection using LO. Our results also suggested that the LO method underestimates the size and number of silicone oil droplets in prefilled syringe products compared to the FI method. The count of particles ≥10mm in size in one product measured using FI exceeded the criteria (6000 counts per container) defined in the compendial particulate matter test using the LO method. Thus precaution should be taken when setting the acceptance criteria of specification tests using the FI method.

Characterisation of Membranes

Porometer’s Instruments

Our porometers can be applied to the characterization of polymeric and ceramic membranes for micro and ultrafiltration applications with pore sizes ranging from 500 μm down to 2 nm. Flat sheet, tubular and hollow fibers can be measured by using an appropriate sample holder.

Best solutions

Both POROLUX™ series and POROLIQ™ series are suitable for membrane characterization as they offer fast and reproducible determination of first bubble point, mean flow pore size, smallest pore, pore size distribution, cumulative flow distribution & gas permeability.

Thanks to the unique designed components to guarantee the most accurate measurement of pressure and flow, and the intuitive and easy to use software, our porometers are the preferred partners of membrane scientists all over the world!

Contact us know to find out the most suitable model for you!

Comparing FlowCam Results with Light Obscuration: A Study by Japan’s National Institute of Health Sciences

In their recent publication, Quantitative Evaluation of Insoluble Particulate Matters in Therapeutic Protein Injections Using Light Obscuration and Flow Imaging Methods, Shibata et. al. compare the ability of Light Obscuration and Flow Imaging to detect and accurately characterize subvisible particles in injectable drugs.

The team at Japan’s National Institute of Health Sciences write the following:

Flow imaging (FI) has emerged as a powerful tool to evaluate insoluble particles derived from protein aggregates as an orthogonal method to light obscuration (LO). However, few reports directly compare the FI and LO method in the size and number of protein particles in commercially available therapeutic protein injections. In this study, we measured the number of insoluble particles in several therapeutic protein injections using both FI and LO, and characterized these particles to compare the analytical performance of the methods. The particle counts measured using FI were much higher than those measured using LO, and the difference depended on the products or features of particles. Some products contained a large number of transparent and elongated particles, which could escape detection using LO. Our results also suggested that the LO method underestimates the size and number of silicone oil droplets in prefilled syringe products compared to the FI method. The count of particles ≥10mm in size in one product measured using FI exceeded the criteria (6000 counts per container) defined in the compendial particulate matter test using the LO method. Thus precaution should be taken when setting the acceptance criteria of specification tests using the FI method.

Read the full publication in the Journal of Pharmaceutical Sciences.

The results of this study corroborate the results produced in our FlowCam lab, comparing particle counts and sizes produced by the two technologies in our new instrument, FlowCam LO.
Our recently produced White Paper, “Measuring Subvisible Particles and Aggregates Using FlowCam LO”, uses FlowCam LO to directly compare the particle size distributions of aqueous samples containing Polystyrene Latex calibration beads, ETFE particles, and IgG aggregates. Download our White Paper to see the results of the study.
FlowCam LO uses two orthogonal techniques in a single instrument by combining our patented flow imaging microscopy technology with an embedded light obscuration particle counter. FlowCam LO provides an even more direct particle count comparison because a single aliquot of sample is analysed by both technologies in one sample run, instead of two samples from the same vial or syringe.