Zeta Potential AnalysisZeta potential is also known as the electro-kinetic potential of a colloid. It refers to the charge repulsion / attraction of particles dispersed in a solution, and is measured by applying an electrical field to the dispersive medium. Researchers commonly perform zeta potential measurements to ascertain the longevity and mechanical stability of a particulate solution, and to establish particle agglomeration characteristics for pharmaceuticals, food products, and more. The DelsaMax Pro is a rapid zeta potential analyser capable of measuring sample volumes as small as 45 microliters (μL) in under a second. This speed of measurement is crucial for maintaining sample stability and supporting zeta potential characterisation of fast-moving consumer goods, as overlong exposure to electrical fields can cause analytes to degrade – reducing experiment throughput and results accuracy.
Dynamic Light Scattering
Ideal for proteins, carbon nanotubes suspensions and emulsions, the speed of analysis means delicate samples such as proteins are not perturbed by the analysis resulting in more reliable and reproducible data. Utilises Dynamic Light Scattering (DLS, sometimes referred to as Quasi-elastic Light Scattering QELS) to determine molecular size simultaneously with Phase Analysis Light Scatter (PALS) to determine Zeta Potential.
Using 32 detectors for zeta potential measurement and a separate detector for sizing the DelsaMax is able to measure zeta potential on samples as low in concentration as the equivalent of 1mg/ml Lysozyme. The incredible speed of the analyser comes in part from its 32-detector array, which allows sensitive detection of particle motion in response to the applied electric field. Rapid detection helps prevent sample degradation that can occur in other slower Zeta potential instruments due to the prolonged exposure of the sample to intense electric fields.
The Assist accessory provides pressurisation of the measurement cell to eliminate gas bubble formation which further improves reliability and reproducibility on samples prone to gassing.
The analyser also utilises a flow cell system requiring only 170 μL of sample, and can be used in-line with industry standard auto-samplers for analysis of multiple formulation samples. For challenging samples with high electrical conductivity that are prone to generating bubbles, the analyser can be used in conjunction with the DelsaMax ASSIST module.
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