FlowCam 8000

Written by Sophie Lindsey on February 8, 2024. Posted in Home page favourites, Products.

Yokogawa Fluid Imaging Technology
FlowCam 8000

Flow Imaging Miscroscopy

Measurement range 2 µm to 1 mm
exceptional image quality
Analyse thousands of particles in less than a minute

Through its exceptional image quality and the widest size range available, FlowCam 8000 represents state-of-the-art particle imaging technology.

Analyse thousands of particles in less than a minute and comprehensively characterise the size, count, morphology, and identity of subvisible and visible particulates in their native solvent.

Overview

Flow Imaging Microscopy (FIM) combines the benefits of digital imaging, flow cytometry, and microscopy into a single solution.

Beyond traditional particle sizing and counting, image-based analysis allows for comprehensive characterization of subvisible API aggregates and contaminants in biopharmaceuticals, mammalian cells, microplankton, emulsions, and advanced materials.

Technical Specs

Size range	Particle sizing and imaging 2 µm to 1 mm with magnification options of 20X, 10X, 4X, and 2X
Minimum sample volume	100 µL
Sample processing capability	Sample processing capability from 0.05 mL/minute up to 10 mL/minute, depending on flow cell configuration
Camera	High-resolution camera available in color or monochrome
Maximum particle concentration	Maximum particle concentration of 5 million particles/mL at 2.5 µm particle size
Additional systems	Compatibility with ALH for FlowCam^(TM) automated liquid handler
Fluorescence excitation options	Fluorescence excitation options (488 nm, 532 nm, 633 nm) with 2-channel fluorescence detection

Benefits
- Obtain meaningful results in less than a minute, with as little as 100 μL of sample
- Sort, filter, and classify images based on 40+ morphological parameters
- Automatically identify particles with out-of-the-box machine learning tools for protein formulations
- Analyze samples in their native environment, including high-viscosity solvents and buffers
- Increase productivity with automated liquid handling for up to 384 samples
- Differentiate aquatic organisms with fluorescence detection in FlowCam 8400
Applications

Advanced Materials

Protein Therapeutics

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LS 13 320 XR

Written by amanda-meritics on February 8, 2024. Posted in Home page favourites, Products. 1 Comment on LS 13 320 XR

Beckman Coulter
LS 13 320 XR

Laser Diffraction Particle Size Analyser

Expanded measurement range 10 nm – 3,500 µm
Enhanced PIDS Technology
Real data down to 10nm

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$Beckman Coulter LS 13 320 XR Laser Diffraction Particle Size Analyser 21 CFR Part 11$

Beckman Coulter LS 13 320 XR Particle Size Analyser

For big improvements that help you spot small differences.

The LS 13 320 XR Particle Size Analyser offers best-in-class particle size distribution data from advanced PIDS technology,* which enables high-resolution measurements and an expanded dynamic range. Like the LS 13 320, the XR particle size analyser provides fast, accurate results, and helps you streamline workflows to optimize efficiency. Some big improvements help you reliably spot small differences that can have a huge impact on your particle analysis data.

Direct measurement range from 10 nm – 3,500 µm
Automatically highlights pass/fail results for faster quality control
Enhanced software that simplifies method creation for standardised measurements
New control standards to adequately verify instrument/module performance

The LS 13 320 XR Particle Size Analyser is an easy-to-use laser diffraction analyser that yields fast, reliable particle size analysis data for dry and aqueous and non-aqueous samples.

Key Features
Spot Small Differences
- Particle Size Analyser with expanded measurement range: 10 nm – 3,500 µm
- Laser diffraction plus advanced Polarization Intensity Differential Scattering (PIDS) technology enable high-resolution measurement & reporting of real data down to 10 nm
- Provides accurate, reliable detection of multiple particle sizes in a single sample
Easy-to-use Software
- ADAPT Software features automatic pass/fail check
- Pre-configured methods deliver results with 3 clicks or less
- Simplifies analyser operation by experts & novice users alike
- 1-click overlay with historical data
- Intuitive user diagnostics keep you informed during sampling
- Simplified method creation for standardised measurements
ADAPT Software enables 21 CFR Part 11
- Customisable security system to meet diverse needs
- Choose from 4 security levels
- High-security configuration supports 21 CFR Part 11
PIDS Technology* for Direct Detection of 10 nm Particles
- 3 light wavelengths (450, 600, & 900 nm) irradiate samples with vertical & horizontal polarized light
- Analyser measures scattered light from samples over a range of angles
- Differences between horizontally & vertically radiated light for each wavelength yield high-resolution particle size distribution data

Technical Specs

Technology	Low-angle forward light scattering with additional PIDS(Polarization Intensity Differential Scattering) Technology. Analysis of vertical and horizontal polarized light at six different angles using three additional wavelengths. Full implementation of both Fraunhofer and Mie Theories.
Light Source	Diffraction: Laser Diode (785 nm) PIDS: Tungsten lamp with high-quality band-pass filters (475, 613 and 900 nm)
Particle size analysis range	Measurement range: 10 nm – 3,500 µm Dry Powder System Module (DPS): 400 nm – 2,000 µm Universal Liquid Module (ULM): 10 nm – 2,ooo µm
Electrical interface	USB
Power consumption	≤ 6 amps @ 90 – 125 VAC ≤ 3 amps @ 220 – 240 VAC
Temperature range	10 – 40°C (50 – 104°F)
Humidity	0 – 90% without condensation
Compliance	Creates 21 CFR Part 11 enabling features RoHS Certifications: – EU EMC Directive 2014/30/EU – CISPR 11:2009/A1:2010 – Australia and New Zealand RCM Mark
Data export file formats	XLSX, TSV, PDF
File import capability	From all LS 13 320 Legacy and LS 13 320 XR system
*Software operating system	Requires Microsoft Windows 10, 64-bit environment (US, English regional settings only)
Dimensions	Height: 19.5″ (49.53 cm) Width: 37″ (93.98 cm) Depth: 10″ (25.4 cm)
Weight	52 lbs (23.5 kg)

Accessories
Dry Powder System

Analytical size range: 400 nm – 3,500 µm
- Measures entire sample as required by the ISO 13 320 Standard
- Programmable Obscuration setting to optimize sample feed rate
- User-selectable vacuum pressure for maximum dispersion control
Universal Liquid Module

Analytical size range: 10 nm – 2,000 µm
- Fully automatic with auto-dilution, auto-filling and auto-rinsing
- Analyses samples suspended in aqueous as well as non-aqueous diluents for maximum flexibility
- Wetted materials list: Teflon®, 316 Stainless Steel, Glass, Kal-rez® and PEEK
Sonicator Control Unit
- Needle probe sonicator for additional dispersion control of wet samples
- Fully adjustable power settings
- In-situ sonication with ULM before/during the run, can also be operated external to module
EU Vacuum Cleaner
- Vacuum pressure range fully adjustable
- Integrated vacuum control unit for optimised vacuum/obscuration settings
- Two vacuum systems to choose from
Applications

Soils

Nanocellulose

Pigments

Cement
Capabilities

The LS 13 320 XR particle size analyzer uses advanced laser diffraction and PIDS technology for the sizing of non-spherical, sub-micron particles. Initially, particle sizing by laser diffraction was limited to the use of the Fraunhofer diffraction theory. Laser diffraction offers a number of advantages – laser diffraction analyzers go beyond simple diffraction effects. General approaches are now based on the Mie theory and the measurement of scattering intensity over a wide scattering angular range is employed.

Using PIDS Technology

Pioneered by Beckman Coulter, most laser diffraction manufacturers use the above two approaches, i.e., wide angular detecting range and short wavelength, to size small particles. However, sizing even smaller particles (tens of nanometers in diameter), cannot be achieved using only these two approaches. Any further increase in scattering angle will not yield any significant improvement due to the everslower angular variation. Figure 2 is a 3-D display that illustrates the very slow angular variation for small particles. For particles smaller than 200 nm, even by taking advantage of the above two approaches, it is still difficult to obtain an accurate size.

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FlowCam 5000

Written by Sophie Lindsey on February 7, 2024. Posted in Home page favourites, Products.

Yokogawa Fluid Imaging Technology
FlowCam 5000

Affordable FIM Analysis (Flow Imaging Microscopy)

Measurement range 3 μm to 300 μm
Compact and Portable
Real data down to 10nm

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$Beckman Coulter LS 13 320 XR Laser Diffraction Particle Size Analyser 21 CFR Part 11$

FlowCam 5000 Affordable FIM Analysis – Experience rapid high-resolution imaging, data acquisition, and analysis of microparticles.

FlowCam 5000 flow imaging instrument is an economical, high-value solution for monitoring particles in the 3 μm to 300 μm size range for research, educational, and commercial applications.

Overview

FlowCam 5000 is a flow imaging microscopy instrument targeted to your specific needs for a wide range of applications. Its compact footprint allows for flexible use in a variety of settings. Accommodate small to large sample volumes for routine and specialised particle monitoring and research. Experience superior image quality and image-based measurements that yield statistically relevant data.
Benefits
- Automate your data collection with a fast, accurate, and easy-to-use alternative to manual microscopy
- Analyse tens of thousands of particles per minute
- Go beyond size and count to analyse shape and type of your particles
- Correlate morphology information with material performance
- Characterise microparticles with as little as 250 µL of sample
- Save time and resources with an instrument optimied for your application

Technical Specs

Size Range	3 μm to 300 μm
Magnification	Single objective (Select 4X or 10X or 20X), manual focus
Minimum sample Volume	250 μL
Sample flow rate	up to 1 mL/min, configuration specific
Camera type	High resolution (1920×1200 pixels) CMOS. Monochrome and color available
Software	Easy-to-use instrument with fully integrated VisualSpreadsheet software

Applications

Food and Beverage

Environmental Research

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Multisizer 4e

Written by Sophie Lindsey on February 7, 2024. Posted in Home page favourites, Products. 1 Comment on Multisizer 4e

Beckman Coulter
Multisizer 4e

Coulter Coulter – Particle Size and Count Analyser

Unparalleled sizing range of 0.2 – 1600 μm
Advanced noise reduction system
Patented digital pulse processing technology

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The Multisizer 4e provides accurate particle and cell counting. It is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 – 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.

Accurate particle and cell counting

The Multisizer 4e Coulter Counter is used in a number of diffrernt fields for counting and sizing both particles and call. Applications include: Quality Control, Research and Development, Pharmaceutical Analysis, Biotechnology Applications and Industrial Applications.

Key Features
Versatility
- Aperture sizes from 10 µm – 2000 µm in diameter for current & future needs
- Multiple aperture options & data overlay capability for analyzing complex samples over wide particle size distribution
Sample Detection
- Analyse materials in aqueous or non-aqueous solvents
- Ideal for biological or non-biological samples
- Detect particles regardless of material type or optical properties
Rapid Particle Counting
- Typical sampling rates up to 10,000 counts per second
- Detect & count particles from 0.2 µm – 1600 µm in diameter
- Sample volumes as small as 5 mL
Data Management
- Digital pulse data can be stored & re-analysed as needed
- CFR 21 Part 11 compliant software for audit control & security
- Variety of calibration beads & V-check validation controls

Technical Specs

Particle Sizing Range	Diameter: 0.2 – 1,600 µm Volume: 0.004 – 2.145 x 10⁹ µm³
Aperture Size	10 – 2,000 µm (nominal diameter)
Measurement range	Extended: 2 – 80% of aperture size Standard: 2 – 60% aperture size
Measurement linearity	Diameter: ± 1% Volume: ± 3%
Dynamic range (accuracy)	Diameter: 1 : 40 (extended), 1 :30 (standard), Volume: 1 : 64,000 (extended), 1: 27,000 (standard)
Processor type	High speed signal digitalisation
Number of pulses measured	Up to 525,000 per analysis
Resolution	User difined
Number of size classes	Up to 400 for display of any selected measurement range The number of classes and their width can be changed as needed
Pulse distribution data	X axis: time, registration sequence, pulse width Y axis: diameter, volume or voltage corresopnding to pulse amplitude, pulse width, mean diameter, volume, or voltage corresponding to pulse amplitude, average pulse width, pulse distribution by width
Particle size distribution data	X axis: diameter, volume, surface area Y axis: absolute number, percent content (%), number per ml, absolute volume, volume percentage (%) volume per ml, absolute surface area (%) surface area per ml
Sample registration mode: total number of particles	50 – 500,000 counts
Sample registration mode: number of particles and measurement of parameters	10 – 100,000 counts
Sample registration mode: time	0.1 – 999 seconds with 10 ms increments Standard registration time is 10 – 90 seconds
Sample registration mode: volume	50 – 2,000 µL
Dosage system	The dosing pump with even suspension flow across the aperture and volume measurement, error – less than 0.5%
Electrolyte type:	Aqueous and non-aqueous electrolyte solutions compatible with glass, fluoropolymers, fluoroelastomers and stainless steel
Aperture current strength range:	30 – 6,000 µA with 0.2µA increments
Aperture current stability:	± 0.4% of set value
Polarity error	Less than 0.5%
Compliance with standards	Software is 21 CFR part 11 compliant
Dimensions	64 x 61 x 51 cm, weight 45 kg
Power supply requirements	230 – 240 V ± 10%, 47 – 63 Hz
Power consumption	Less than 55 Watts
Fuses	250 V, IEC (5×20 mm) with time delay, 2.0 A
Environmental requirements	The instrument is intended for work in enclosed spaces Working temperature: 5 – 40°C Relative humidity: 30 – 85% without condensation

Applications

Yeast

Beer

Protein

E. coli

Plant Cells

CAR-T Cells
Capabilities
The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 – 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.

Generated data are processed using patented digital pulse processing technology and can be saved and later re-analyzed. This technology provides ultra high resolution and accuracy unattainable through any other technologies: detection of 1 particle in 1 ml of a sample with the optimal instrument configuration. Analysis results are not dependent on particle shape, structure, or optical properties.

It uses the Coulter principle to detect particles via electrical zone sensing, regardless of the particle’s nature or optical properties. This makes it an ideal tool for detecting and counting a wide variety of particles, such as:
- Mammalian cells
- Bacteria
- Yeast
- Abrasives
- Toner particles
- Cell aggregates
- Spheroids
- Large protein aggregates
More information from
Beckman Coulter

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Bettersizer S3 Plus

Written by Sophie Lindsey on February 6, 2024. Posted in Home page favourites, Products.

Bettersize
Bettersizer S3 Plus

Particle Size and Shape Analyser

0.01 – 3,500 µm (laser system)
2 – 3,500 µm (image system)
0.5x and 10x cameras
Rapidly generates results in 10 seconds

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Strive for excellence in all you see.

The Bettersizer S3 Plus particle size and shape analyser combines laser diffraction and dynamic image analysis in one instrument. It can measure the size and shape of particles from 0.01 µm to 3500 µm. Its exceptional sensitivity for either ultrafine particles or oversized particles, and unsurpassed resolution, make it the most powerful size and shape analyser for enthusiastic researchers who conduct top scientific research.

Features and Benefits
- Measuring range is 0.01 – 3,500µm (laser system), 2 – 3,500µm (image system)
- Combining laser diffraction and dynamic image analysis in one instrument, obtaining size and shape results simultaneously
- Patented DLOI (Dual Lenses & Oblique Incidence) system enable the measurement of ultrafine particles down to 0.01 µm
- Dual-camera imaging technology can show particles images in real time and detect oversized particles up to 3500 µm
- Refractive index measurement determines the refractive index of unknown samples and improves te reliability of results
- Compliance with 21 CFR Part 11, ISO 13320, USP <429>, CE
Performance

1) High Resolution and Sensitivity

The Bettersizer S3 Plus achieves exceptional resolution and sensitivity for particle size measurements. The DLOI system allows the size distributions of polydisperse samples to be determined precisely, and the size changes of products to be detected sensitively.

2) Multiple Shape Parameters

An example of additive manufacturing for shape analysis using the Bettersizer S3 Plus is shown below. A representative number of individual particles are recorded from two AlSi10Mg samples, and the number-weighted aspect ratio and circularity are evaluated in compliance with ISO standards. (Adapted from F. Schleife, C. Oetzel. Chem. Ing. Tech. 93.8 (2021): 1199–1203.)

3) Oversized Particle Detection

Laser diffraction in combination with image analysis can sensitively detect oversized particles that are statistically underrepresented within a wide-distributed sample, such as oversized grains, agglomerates, air bubbles, etc. An example of an off-specification abrasive is displayed below. The Bettersizer S3 Plus confirms the presence of oversized particles, by showing a size peak at around 120 μm and the images of overly coarse particles.

4) Analysis of Samples with Extremely Broad Distributions
Technology

Image Analysis

Laser Diffraction
Applications

Soy Milk

Advanced Ceramic Products

Powder Coatings

Ceramic Agglomerates

Lithium-Ion Batteries

Soils and Sediments

Abrasives

3D Printing

Differing Abrasives

Specification

Particle size distribution	Suspension, emulsion, dry powders
Particle shape	Suspension, emulsion, dry powders
Principle	Laser diffraction and dynamic image technologies
Analysis	Mie scattering theory and Fraunhofer diffraction theory
Typical measurement time	Less than 10 seconds
Measuring range	0.01 – 3500 μm (Laser System) 2 – 3500 μm (Image System)
Accuracy	<0.5% (NIST certified standards)
Repeatability	<0.5% (NIST certified standards)
Number of size classes	≤100 (adjustable)
Feeding mode	Automatic circulation or semi-automatic circulation
Special functions	Refractive index measurement, SOP settings
Image recognition	Up to 120 fps, up to 10,000 particles per min
Optical system	Patented DLOI (Dual Lenses & Oblique Incidence) System
Laser	Polarized light-pumped solid-state laser (10 mW / 532 nm)
Detector	96 detectors (forward, lateral and backward arrangements)
Measuring angle	0.02 – 165°
CDC cameras	0.5x and 10x *
Image analysis	1.2 megapixels
Circulation speed	300 – 2500 r/min
Circulation flow rate	3000 – 8000 mL/min
Ultrasonication	Dry run protection, Max 50 W (adjustable)
Circulation tank capacity	600 mL
Conformity	21 CFR Part 11, ISO 13320, ISO 13322, USP <429>, CE
Report	Customizable reporting
Dimensions (L x W x H)	820 × 610 × 290 mm
Weight	48 kg
Voltage	DC 24 V, 50 / 60 Hz, 20 W
Computer interface	At least one high-speed USB 2.0 or USB 3.0 port required
Operating system	Windows 7 / Windows 10
Hardware specification	Intel Core i7, 8GB RAM, 500GB HD, two PCI-E X16 interfaces

* The Bettersizer S3 Plus is also available in a single camera (0.5x) model. Contact us for more information.

Accessories
Introduction

The BT-A60 is a durable, automatic and high-throughput sampling system. It delivers maximum laboratory automation for sample measurements, reducing your labor costs while improving productivity and laboratory efficiency. The compact design saves valuable bench space while allowing up to 60 different samples to be measured in a single run. Compatible with Bettersizer S3 Plus and Bettersizer 2600, the BT-A60 offers 24/7 fully automated sample analysis to meet your various analytical applications.

Features
- Accurate sample identification
- Efficient ultrasonic cleaning
- Up to 60 samples in one click
- Measurement automation
- Small footprint
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FlowCam 8000

Yokogawa Fluid Imaging Technology FlowCam 8000

Flow Imaging Miscroscopy

Overview

Technical Specs

Benefits

Applications

Advanced Materials

Protein Therapeutics

Not sure if it’s the right instrument?

No worries, send us a sample and we will test it for you

LS 13 320 XR

Beckman Coulter LS 13 320 XR

Laser Diffraction Particle Size Analyser

Beckman Coulter LS 13 320 XR Particle Size Analyser

Key Features

Spot Small Differences

Easy-to-use Software

ADAPT Software enables 21 CFR Part 11

PIDS Technology* for Direct Detection of 10 nm Particles

Technical Specs

Accessories

Dry Powder System

Universal Liquid Module

Sonicator Control Unit

EU Vacuum Cleaner

Applications

Soils

Nanocellulose

Pigments

Cement

Capabilities

Using PIDS Technology

Not sure if it’s the right instrument?

No worries, send us a sample and we will test it for you

FlowCam 5000

Yokogawa Fluid Imaging TechnologyFlowCam 5000

Affordable FIM Analysis (Flow Imaging Microscopy)

Overview

Benefits

Technical Specs

Applications

Food and Beverage

Environmental Research

Not sure if it’s the right instrument?

No worries, send us a sample and we will test it for you

Multisizer 4e

Beckman CoulterMultisizer 4e

Coulter Coulter – Particle Size and Count Analyser

Accurate particle and cell counting

Key Features

Versatility

Sample Detection

Rapid Particle Counting

Data Management

Technical Specs

Applications

Yeast

Beer

Protein

E. coli

Plant Cells

CAR-T Cells

Capabilities

More information from Beckman Coulter

Not sure if it’s the right instrument?

No worries, send us a sample and we will test it for you

Bettersizer S3 Plus

BettersizeBettersizer S3 Plus

Particle Size and Shape Analyser

Features and Benefits

Performance

1) High Resolution and Sensitivity

2) Multiple Shape Parameters

3) Oversized Particle Detection

4) Analysis of Samples with Extremely Broad Distributions

Technology

Image Analysis

Laser Diffraction

Applications

Yokogawa Fluid Imaging Technology
FlowCam 8000

Beckman Coulter
LS 13 320 XR

Yokogawa Fluid Imaging Technology
FlowCam 5000

Beckman Coulter
Multisizer 4e

More information from
Beckman Coulter

Bettersize
Bettersizer S3 Plus