ViewSizer 1000
Horiba
ViewSizer 1000
Multi-Variable Pulse Nanoparticle Tracking Analysis (NTA)
- Measurement range 10 nm to 15 µm
- Advanced NTA with a single laser
- Repeatable results with minimal sample handling

The ViewSizer™ 1000 combines the advantages of multispectral NTA with the simplicity of a single laser system by utilizing multi-variable pulse nanoparticle tracking analysis (MVP NTA).
Achieving efficient, repeatable, reproducible, and accurate measurements of nanoparticles size distribution and concentration remains a challenge for complex samples, such as extracellular vesicles (EVs), ultra-fine bubbles, liposomes, viruses, proteins, and colloids. Light scattering techniques, such as laser diffraction and dynamic light scattering (DLS) yield fast and accurate average size, but details are lost due to their ensemble nature.
Nanoparticle tracking analysis (NTA) overcomes this limitation by analyzing individual particles. The ViewSizer 1000, driven by MVP NTA, offers a new patented approach that overcomes these issues without the complexity of multispectral NTA.
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Key Features
- Collect accurate data for all particles in a sample, even for wide-size distributions, using patented multi-variable pulse technology (MVP NTA).
- Excellent repeatability and reproducibility due to stable optics, temperature control, and effective, unbiased mixing.
- Access larger particle sizes with high spatial resolution NTA for slowly moving particles, including sedimentation analysis.
- Prevent cross-contamination and increase throughput by using easily washed and replaced cuvettes.
- Flexible analysis with user access to laser intensity, camera gain, pulse duration, and frame rate settings.
- Recommended and robust default method settings for many applications are included with the system.
- Solvent resistant (wetted materials: glass/quartz, fluoropolymers, and anodized aluminum, glass/fluoropolymer cells also available)
- Reduced sample volume due to no feed tubing or pump required.
Introducing Multi-Variable Pulse NTA
Using next generation hardware and software, a series of varying pulse widths are used in place of varying laser powers. Each pulse width has its own independent sequence of video frames. Long pulse frames have good data on small particles, while short pulse frames have good data on large particles. Position as a function of time, that is particle movement, is then analyzed by the Stokes-Einstein relationship to extract particle size for each particle in the sample.
Since sample volume is well known, along with the number of particles images, particle number concentration is determined without any further information required. Random mixing with a stir bar (not slow flow through a tube) ensures random selection of particles for each video without the biases of a flow-based system. The instrument automatically sums the particles identified in each video and divides by the measurement volume to calculate the sample concentration.
Thus, detailed particle size distribution and concentration is rapidly measured in a single system.
Advanced Software
The ViewSizer software is designed for intuitive workflow. Data collection can be initiated with just a few clicks, with results generated in multiple exportable formats for downstream analysis. The user interface includes real-time visualization of all particles – providing valuable insights into sample behavior and data quality.
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Technical Specs
Measurement Range10 nm to 15 μm
Sample Volume100 microliters to 2.5 mL
Sample Concentration (Sample dependent)1E5 to 1E9 p/mL
Dimensions55 cm (W) x 66 cm (D) x 35 cm (H)
Operational Environment15°C to 30°C with <85% RH
(Dry gas purge feature allows operation below dew point)Electrical100 to 240 VAC, 47-63 Hz inclusive, <450 Watts
Class 1 Laser21 CFR Ch. I part 1040
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